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¿Le supone algún problema?

Would that be a problem for you?

Politeness Phrases
Notes & Usage:

Considerate way to check if a plan, request, or change causes any inconvenience. Shows awareness of the other person's situation.

See It in Context

Cambiaríamos la reunión al jueves. ¿Le supone algún problema?

We'd move the meeting to Thursday. Would that be a problem for you?

Necesitaría el informe antes del viernes. ¿Le supone algún problema?

I'd need the report before Friday. Would that be a problem for you?

—¿Le supone algún problema? —En absoluto, sin problema.

—Would that be a problem for you? —Not at all, no problem.