After all / At the end of the day / When all is said and done
Used to cut through complexity and state what really matters. Signals the speaker is arriving at the essential point after considering everything.
After all, the important thing is that you're OK.
At the end of the day, we're friends, aren't we?
—Is it worth it? —After all, yes.
After all, he was right.
In the end, it doesn't matter.